KEVIN DESISTO, PH.D

KEVIN DESISTO, PH.D

KEVIN DESISTO, PH.D

Dedicated to science knowledge —
from innovative chemistry
to writing and consulting/tutoring


BIO

Hello and welcome to my professional web space. I am Kevin DeSisto, Ph.D., a nature enthusiast that has a wealth of knowledge and experience in the scientific world. I acquired my Ph.D. in Organic Chemistry at the University of Vermont (UVM) under the expert tutelage of Dr Jose S. Madalengoitia. Dr. Madalengoitia was a student of the legendary Dr, Larry Overman at UC Irvine and the mentor of noble prize laureate Dr. David McMillan (2021). Having 10 years of education, 10 years of corporate experience, and 10 years of running my own laboratory I have a wealth of proficiency teaching and performing chemistry at the highest level. After working for the pharmaceutical industry and developing several drug candidates for three different companies, I took the knowledge and applied it to the natural world. Using analytical instrumentation, chemical synthesis, and knowledge of signal transduction pathways I helped elucidate the enigma of cannabis derived cannabinoids. When marijuana was first legalized the FDA, which is the only governing body for drugs, chose to ignore the state level movement. Since there is no state-level FDA agency that is equivalent, in 2011 I quickly stepped in to demand standardized safety testing for public health and not only produced cannabis chemical standards, but I also started to develop a standardized assay. I continue to be an efficiency and logistics expert as well as helping to promote health and safety for the planet.

PHD THESIS

Abstract:
Methodology for the solid-phase reductive amination and reductive alkylation of PTAA toward lysine libraries has been developed. A PTAA is attached to a solid support and, in the case of reductive alkylation, a nitrogen side chain is subjected to imine formation by reaction with an aldehyde of desired functionality. Hydride reduction of the imine to the amine follows to furnish the lysine analog upon cleavage from the solid support. Reductive amination is the reaction of an aldehyde side chain with an amine of desired functionality followed by reduction of the imine. These methods allow for the generation of lysine libraries with potentially limitless functionality, as a secondary or tertiary amine, without the time of developing a process for each analog.
Continue to full Thesis Presentation

BOOKS AND PUBLICATIONS

DeSisto, K.; Madalengoitia, J.S. “Synthesis and Conformational Analysis of 3-Substituted Proline Templated Amino Acids” Ph.D. Thesis – UVM Bridgeport National (RD21 0019), 2004

Prakash, J.G.; Baloglu E.; Southan G.; Williams W.; Roy A.; Nivorozhkin A.; Landrau, N.; Desisto, K.; Salzman, A.L.; Szabó, C. “Facile and Convenient Syntheses of 6,11-Dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-Dihydro-5H-indolo[3,2-c]isoquinolin-5-one” Org. Lett., 2005, 7, 1753 - 1756

DeSisto, K.S., "Efficient Nutrition to Amplify Your Health" Smashwords, 2015 ISBN: 9781310183362

CONSULTING AND TUTORING

Consultant / Subject Matter Expert: A) Pharmaceutical Chemistry B) FDA Compliance C) Product & Process Development D) Natural Products

Chemistry Tutor: A) Organic, AP & biochemistry B) GRE, MCAT, DAT prep C) Graduate level education includes: pharmacology, mass spectrometry, chemical structure elucidation (e.g. NMR)

Technical writer & editor

KEVIN DESISTO

info@ksdphd.com